胡正教授

胡正，吉林大学第一医院，教授，博士生导师；国家高层次青年人才；现任吉林大学器官再造与移植教育部重点实验室副主任；中国科学技术大学本科(2005)、博士(2010)，中国科学技术大学/美国哈佛大学医学院麻州总医院联合培养博士(2008-2011)，美国哥伦比亚大学博士后(2011-2013)。主持中科院A类先导专项、国自然重点、面上项目等；以第一/通讯作者在Nature Biomedical Engineering, Blood, Cell Mol Immunol, JCI Insight, Transplantation, J Immunol, Eur J Immunol, Stem Cell Rep、Xenotransplantation等杂志发表论文30余篇，论文被引用1000余次；主要成绩包括：①首次构建具有人造血免疫系统重建的人源化猪模型；②构建新型低免疫原性基因编辑猪，并实现猪-猴异种肾移植存活超过120天；③首次实现人红细胞和人血小板在小鼠体内高水平重建；④研发多类适于不同人类疾病研究的人源化小鼠模型；获吉林省科技成果转化贡献奖（2021年），吉林省自然科学一等奖（2022年；第三）

研究方向：

（1）人源化猪模型与人源化器官再造：研发人源化猪模型，开展人类功能细胞（如Naïve CAR-T、CAR-NK、红细胞、血小板等）活体规模化再生研究；利用免疫缺陷猪为载体，开展“人源化器官”异种再造研究；

（2）异种器官移植：研究异种移植免疫排斥机制，构建低免疫原性高免疫/生理兼容性基因编辑猪及有效免疫干预策略，推动异种移植临床转化，解决临床器官短缺难题。

（3）人源化小鼠模型研究：研发细胞、组织、器官高度人源化的小鼠模型，模拟人类疾病发生，促进新药物/疗法临床转化。

发表论文:

1. Long-term engraftment of human stem and progenitor cells for large-scale production of functional immune cells in engineered pigs. Zheng Hu, Jun Zou, Zhengzhu Wang, Kai Xu, Tang Hai, Sheng Zhang, Peipei An, Cong Fu, Shuai Dong, Yanan Lv, Jilong Ren, Zhiqiang Han, Chongyang Li, Jing Wang, Qingwei Wang, Renren Sun, Long Su, Hanjing Zuo, Qinghao Ding, Huimin Tian, Xinlan An, Yanhui Zhai, Dawei Yu, Chang Shu, Jin He, Liguang Sun, Tianmeng Sun, Xiangpeng Dai, Ziyi Li, Wei Li, Qi Zhou & Yong-Guang Yang.Nature Biomedical Engineering.2025 May online. https://doi.org/10.1038/s41551-025-01397-6

2. Development of a humanized mouse model with functional human materno-fetal interface immunity. Dong S, Fu C, Shu C, Xie M, Li Y, Zou J, Meng YZ, Xu P, Shan YH, Tian HM, He J, Yang YG, Hu Z.  JCI Insight 2024 Oct 22;9(20):e176527.

3. Current status and challenges of pig-to-human organ xenotransplantation. Fang M, Yang YG, Hu Z. Sci China Life Sci. 2024 Apr;67(4):829-831. doi: 10.1007/s11427-023-2500-9. Epub 2023 Dec 29.

4. Modeling human anti-pig xenoimmune responses in a pig artery tissue grafted humanized mouse model. Fang M, Zou J, Xu F, Wang X, Hua S, Zhou Q, Yang YG, Hu Z. Xenotransplantation. 2023 Sep-Oct;30(5):e12824.

5. Genome editing HLA alleles for a pilot immunocompatible hESC line in a Chinese hESC bank for cell  therapies. Ji TT, Niu SS, Fang MH, Xu LX, Wang X, Zou J, Xu F, Zhang M, Niu R, Wu J, Wang L, Li ZK,Yang YG, Hao J*, Li W*, Hu Z*, Zhou Q*.Cell Prolif 2023 May;56(5):e13471

6. Induction of local immunosuppression in allogeneic cell transplantation by cell-type-specific expression of PD-L1 and CTLA4Ig. Zhu W, Li M, Zou J, Zhang D, Fang M, Sun Y, Li C, Tang M, Wang Y, Zhou Q, Zhao T, Li W, Hu Z, Hu B. Stem Cell Reports. 2023 Dec 12;18(12):2344-2355.

7. Humanized mice for investigating SARS-CoV-2 lung infection and associated human immune responses.  Sun R, Zhao Z, Fu C, Wang Y, Guo Z, Zhang C, Liu L, Zhang C, Shu C, He J, Yang YG, Hua S, Gao Y, Hu Z. Eur J Immunol. 2022 Oct;52(10):1640-1647.

8. Exploration of Human Lung-Resident Immunity and Response to Respiratory Viral Immunization in a Humanized Mouse Model. Wang Y, Wang L, Fu C, Wang X, Zuo S, Shu C, Shan Y, He J, Zhou Q, Li W, Yang YG*, Hu Z*, Hua S*.  J Immunol. 2022 Jan 15;208(2):420-428.

9. Posttransplant blockade of CXCR4 improves leukemia complete remission rates and donor stem cell engraftment without aggravating GVHD. Su L, Fang MH, Zou J, Gao SJ, Gu XY, Meng XD, Wang X, Hu Z*, Yang YG*. Cell Mol Immunol. 2021 Nov;18(11):2541-2553

10. Generation of GGTA1-/-β2M-/-CIITA-/- pigs using CRISPR/Cas9 technology to alleviate xenogeneic  immune reactions, Fu R, Fang MH, Xu K, Ren JL, Zou J, Su L, Chen XX, An PP, Yu DW, Ka MN, Hai T, Li ZY, Li W, Yang YG, Zhou Q, Hu Z;  Transplantation, 2020 Aug;104(8):1566-1573.

11. IL2RG-deficient minipigs generated via CRISPR/Cas9 technology support the growth of human melanoma-derived tumours. Ren J, Yu D, Fu R, An P, Sun R, Wang Z, Guo R, Li H, Zhang Y, Li Z, Yang YG, Li W, Hai T, Hu Z. Cell Prolif. 2020 Oct;53(10):e12863.

12. Complement depletion improves human red blood cell reconstitution in immunodeficient mice. Chen B, Fan W, Zhang SW, He J, Shu C, Zhao GQ, Sun TM, Hu Z*, Yang YG*. Stem Cell Reports 2017 Oct 10;9(4):1034-1042.

13. Antithymocyte globulin treatment at the time of transplantation impairs donor hematopoietic stem cell  engraftment. Jin F, He J, Jin C, Fan W, Shan Y, Zhang Z, Sun L, Hu Z*, Yang YG*.Cell Mol Immunol 2017 May;14(5):443-450

14. Macrophages prevent human red blood cell reconstitution in immunodeficient mice.Hu Z, Van Rooijen N, Yang YG. Blood 2011 Nov 24; 118(22):5938-46

15. Full reconstitution of human platelets in humanized mice after macrophage depletion. Hu Z, Yang YG. Blood 2012 Aug 23;120(8):1713-6.